Synthesis and Antimicrobial Activities of a Series of Disubstituted arylazo-Barbituric- and Thiobarbituric Acid Derivatives

Authors

  • Ahmed K. Oraby Department of Chemistry, Memorial University of Newfoundland, St. John
  • Khaled R. A. Abdellatif Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni - Suef University, Beni Suef,
  • Mohamed A. Abdelgawad Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni - Suef University, Beni Suef,
  • Khadiga M. Attia Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Misr University for Science and Technology, Al - Motamayez District, 6th of October City, P.O. Box 77,
  • Paris Elias Georghiou Memorial University of Newfoundland

DOI:

https://doi.org/10.7439/ijpc.v6i4.3164

Abstract

A simple, convenient and reproducible synthesis of several new disubstitutedarylazo-barbituric and thiobarbituric acids is described. The method involves condensation with urea and thiourea of 2,4-disubstituted phenylhydrazones formed from the reactions of the parent aniline diazonium salts with diethylmalonate. These new compounds were preliminary evaluated for their antimicrobial activities against five bacterial strains covering both (Gram positive and Gram negative bacterial strains) and two fungi. Three of the newly-synthesized compounds showed promising antimicrobial activities with no signs of human cells cytotoxicity.

Downloads

Downloads

Published

2016-05-11

Issue

Vol. 6 No. 4 (2016): Apr

Section

Research Articles

License

Copyright (c) 2016 International Journal of Pharmaceutical Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
  • The author must submit Copyright form After acceptance of the article.

How to Cite

1.
Synthesis and Antimicrobial Activities of a Series of Disubstituted arylazo-Barbituric- and Thiobarbituric Acid Derivatives. Int J of Pharm Chem [Internet]. 2016 May 11 [cited 2025 Jun. 8];6(4):100-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3164
Crossref
Scopus
Google Scholar
Europe PMC