Quantitative estimation of Donepenzil hydrochloride tablet by HPLC

Authors

  • Sadath Ali Glocal School of Pharmacy, Glocal University, Saharanpur, U.P
  • Mohamad Taleuzzaman Glocal University, Saharanpur.U.P.
  • Sadaf Jamal Gilani Glocal School of Pharmacy, Glocal University, Saharanpur, U.P
  • Md Liyakat Ahmed Department of Biotechnology, Acharyanagarjuna University, Guntur, A.P
  • Abdul Hafeez Glocal School of Pharmacy, Glocal University, Saharanpur, U.P

DOI:

https://doi.org/10.7439/ijpc.v6i2.3022

Abstract

A simple, rapid, reliable and accurate HPLC method has been developed and validated as per the ICH guidelines for the quantitative determination of Donepezil HCl in bulk and tablets. The water HLC-10, high performance liquid chromatography system were used. The LOQ is detected at concentration 0.05mg/ml and the linearity range is 50-150g/ml. An optimum concentration scanned in the range 200-350 nm and ? max of the drug is 230 nm. No any interference at developed (R t = 8.22 min) and also the ? max peak is sharp. The Accuracy of the method was found to be in the range of 99.70% to 100.26%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 0.69%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Donepezil in tablet formulations and can be used for commercial purposes.

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Published

2016-02-29

Issue

Vol. 6 No. 2 (2016): Feb

Section

Research Articles

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How to Cite

1.
Quantitative estimation of Donepenzil hydrochloride tablet by HPLC. Int J of Pharm Chem [Internet]. 2016 Feb. 29 [cited 2025 Jun. 18];6(2):62-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3022
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