Separation of racemate hydrophobic thiourea substrates

Authors

  • Inas EL Hassan Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli
  • Fatm Houmaissi Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli
  • Mohammad Bouchekara Department of Chemistry, Faculty of Sciences and Technologies, University Mustapha Stanbouli of Mascara (29000)
  • Hanna El-Nakat Department of Chemistry, Faculty of Science, University of Balamand, P.O. Box 100, Tripoli
  • Fawaz El Omar Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli
  • Ahmad Khodr Allouch Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli,

DOI:

https://doi.org/10.7439/ijpc.v6i3.2931

Abstract

The separation of racemic-N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, a hydrophobic substrate trap, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RP-HPLC). Hydroxypropyl-beta-cyclodextrin (HP-?-CD) was used as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-ethanol (50% in volume) as a mobile phase. The effects of mobile phase composition, on separation were systematically investigated to establish the optimum conditions of resolution.

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Author Biography

  • Ahmad Khodr Allouch, Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli,
    Department of Chemistry, Professor

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Published

2016-03-30

Issue

Vol. 6 No. 3 (2016): Mar

Section

Research Articles

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How to Cite

1.
Separation of racemate hydrophobic thiourea substrates. Int J of Pharm Chem [Internet]. 2016 Mar. 30 [cited 2026 Jan. 4];6(3):87-91. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2931
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