Synthesis, Characterization and antimicrobial activity of azole-pyrazolidin-3-one derivatives
DOI:
https://doi.org/10.7439/ijpc.v5i12.2793Abstract
Pyrazole derivatives have attracted considerable attention in last decade in view of diverse chemotherapeutic potential including anti-cancer. In the present research work some derivatives of pyrazole, 4-(1H-imidazol-1-yl)-5-phenylpyrazolidin-3-one (4a-g) , were synthesized by treating the corresponding hydrazones with base in moderate yields. The synthesized derivatives were characterized by FT-IR, 1 H NMR and Mass spectroscopy and screened for in vitro antimicrobial activity. The compounds 4c, 4f and 4g showed significant antimicrobial activities.Downloads
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