Spectral Characterization and Antimicrobial screening of a few Mannich bases

Authors

  • Syed Ali Padusha M PG and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620020, Tamil Nadu
  • Mashood Ahamed PG and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620020, Tamil Nadu http://orcid.org/0000-0001-6606-7708

DOI:

https://doi.org/10.7439/ijpc.v5i11.2757

Keywords:

cardiorespiratory fitness, cardiovagal control, electrocardiography, heart rate variability

Abstract

Some new Mannich bases (1a-5a) were synthesized by reacting morpholine with various aldehydes and the compounds containing active hydrogen atoms(acetophenone, thiourea and pheny urea). Structures of the compoundswere confirmed by IR, 1 H-NMR, 13 C-NMR and mass spectra. Antimicrobial Studies were carried out for the synthesized compounds against various bacterial and fungal strains employing Ofloxacin as standard drug for antibacterial and amphotericin B as standard drug for anti fungal screening. The compounds 1a-3a and 5a have been possessed high antibacterial activity and the compounds 3a and 5a showed higher zone of inhibition against fungal strains. Particularly the compound 3a exhibit higher zone of inhibition against A.niger and the compound 5a showed higher activity against A.niger and Trichophyton.

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Published

2015-11-30

Issue

Vol. 5 No. 11 (2015): Nov

Section

Research Articles

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How to Cite

1.
Spectral Characterization and Antimicrobial screening of a few Mannich bases. Int J of Pharm Chem [Internet]. 2015 Nov. 30 [cited 2025 May 25];5(11):392-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2757
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