Homology modeling of Candida Albicans lanosterol 14 ?- demethylase and validation of the homology model
DOI:
https://doi.org/10.7439/ijpc.v5i11.2716Keywords:
Homology ModelingAbstract
The cytochrome P450 sterol 14?-demethylase enzyme (CYP51) is the target of azole antifungals. Azoles block ergosterol synthesis, and thereby inhibit fungal growth, by binding in the active-site cavity of the enzyme and ligating the iron atom of the heme cofactor through a nitrogen atom of the azole. In this work, homology models of the CYP51 enzymes from Candida albicans were constructed based on the X-ray crystal structure of CYP51 from Saccharomyces cerevisiae .
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Published
2015-11-30
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Research Articles
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1.
Homology modeling of Candida Albicans lanosterol 14 ?- demethylase and validation of the homology model. Int J of Pharm Chem [Internet]. 2015 Nov. 30 [cited 2026 Jan. 3];5(11):367-74. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2716
