Synthesis and evaluation of anti-cancer activity of some 6-Aminoflavones

Authors

  • Lalitha Simon Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal, 576 104,
  • K. K. Srinivasan Department of Chemistry, Shri Madhwa Vadiraja Institute of Technology & Management, Visvesvaraya Technological University, Bantakal, Udupi, 574115
  • C. Mallikarjuna Rao Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104,
  • Nitesh Kumar Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104,
  • Neetinkumar Reddy Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104,
  • Subhankar Biswas Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104,
  • Sudheer Moorkoth Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104

DOI:

https://doi.org/10.7439/ijpc.v5i7.2220

Keywords:

6 - Aminoflavones

Abstract

A series of 6-Aminoflavones (5a-o ) was synthesized and characterized by spectral techniques. Their cytotoxic effects have been evaluated in vitro in relation to colon HCT116 and breast MCF7 cancer cell lines, using MTT assay. The findings revealed that compound 5n had significant cytotoxic effects against HCT116 and MCF7 with IC50 values of 30.02 ?M and 40 ?M respectively. The compound 5o showed lowest IC50 value of 29.5 ?M against HCT116 cell line. Acridine orange ethidium bromide staining was used to assess the morphonuclear changes in HCT-116 treated with the test compound 5o. 5o showed 38% apoptotic nuclei. Flow cytometric studies on HCT-116 cell line treated with 5o showed the arrest of cell cycle in G0/G1 phase.

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Published

2015-07-30

Issue

Vol. 5 No. 7 (2015): Jul

Section

Research Articles

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How to Cite

1.
Synthesis and evaluation of anti-cancer activity of some 6-Aminoflavones. Int J of Pharm Chem [Internet]. 2015 Jul. 30 [cited 2025 May 24];5(7):240-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2220
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