Effects of mono and dinuclear copper(II) complexes derived from non-steroidal anti-inflammatory drug naproxen on human serum paraoxanase1 (PON1) activity
DOI:
https://doi.org/10.7439/ijpc.v5i6.2094Abstract
The inhibition of human paraoxonase 1 (PON1, EC 3.1.8.1) enzyme, with two Cu(II) complexes derived from naproxen was investigated by using the paraoxonase activity method with diethyl 4-nitrophenyl phosphate as substrate. The complexes [Cu 2 (-nap) 4 (3-pic) 2 ] (1) and [Cu(nap) 2 (H 2 O)(4-pic) 2 ] (2) decreased the in vitro PON1 activity with different inhibition mechanisms. The inhibition mechanism of complex 1 was uncompetitive whereas complex 2 was noncompetitive inhibitors. In this study, complexes mentioned above showed effective inhibitory activity on PON1. IC 50 values for [Cu 2 (-nap) 4 (3-pic) 2 ] (1) and [Cu(nap) 2 (H 2 O)(4-pic) 2 ] (2) were of 0.109 mM and 0.103 mM for PON1, respectively. K i values for complex 1 and complex 2 were of 0.116 mM and 0.121 mM for PON1, respectively.Downloads
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Published
2015-06-30
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How to Cite
1.
Effects of mono and dinuclear copper(II) complexes derived from non-steroidal anti-inflammatory drug naproxen on human serum paraoxanase1 (PON1) activity. Int J of Pharm Chem [Internet]. 2015 Jun. 30 [cited 2026 Mar. 12];5(6):189-95. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2094
