Synthesis, characterization and antimicrobial screening of some substituted 1, 3, 4 aryl oxadiazole derivatives

Authors

  • Deepak Sitaram Musmade
  • Shashikant R Pattan
  • Manjunath S. Yalgatti Head, Department of Pharmaceutical chemistry, Srikrupa Institute of Pharmaceutical Sciences, Vill: Velkatta, Mdl: Kondapak, Rd: Siddipet, Dist: Medak. 502277 Telangana state

DOI:

https://doi.org/10.7439/ijpc.v5i5.2005

Abstract

The plethora subscribed in this research is directed towards the synthesis of 1, 3, 4-aryl oxadiazole derivatives. The acid hydrazide of Mefenamic acid and Diclofenac undergoes Schiffs reaction with substituted aromatic aldehyde to offer aryl hydrazones which upon treatment with an aromatic acid and phosphorous oxychloride offers corresponding substituted 1, 3, 4-ary-oxadiazole derivatives. The structures of the synthesized compounds were established by IR, 1H-NMR, MS and elemental analysis. The synthesized compounds were screened for their anti bacterial and anti-fungal activities.

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Published

2015-05-30

Issue

Vol. 5 No. 5 (2015): May

Section

Research Articles

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How to Cite

1.
Synthesis, characterization and antimicrobial screening of some substituted 1, 3, 4 aryl oxadiazole derivatives. Int J of Pharm Chem [Internet]. 2015 May 30 [cited 2025 May 27];5(5):166-71. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/2005
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