Pharmaceutical evaluation of effects of hydrophilicity and hydrophobicity of three commonly used diluents on tablet formulation-Part II: SR tablets
DOI:
https://doi.org/10.7439/ijpc.v5i3.1921Keywords:
Subclinical Hypothyroidism, lipid profile, Total Cholesterol, LDL, HDL, dyslipidemiaAbstract
Effects of hydrophilicity and hydrophobicity of three commonly used diluents on characteristics and functioning of sustained release tablets were assessed. Tablets of model soluble and insoluble drugs were formulated with HPMC and ethyl cellulose. Hardness, friability, disintegration, contact angle, wettability and dissolution of tablets were studied. These sustained release formulations were noticeably affected by hydrophilicity and hydrophobicity of drug and diluents and should be meticulously given a thought.Downloads
References
Fan TY, Wei SL, Yan WW, Chen DB, Li J. An investigation of pulsatile release tablets with ethylcellulose and eudragit L as film coating materials and cross linked polyvinyl pyrrolidone in the core tablets. J Contr Release. 2001;77:245-251.
Levina M, Rajabi- Siahboomi AR. The influence of excipients on drug release from HPMC matrices. J Pharm Sci. 2004;93 (11):2746-2754.
Alderman DA. A review of cellulose ether in hydrophilic matrices for oral controlled release dosage forms. Int J Pharm Techno Prod Mfr. 1984;5:1
Ranga Rao KV, Padmalatha DK, Buri P. Cellulose matrices for zero-order release of soluble drugs. Drug Dev Ind Pharm. 1988;14:2299
Martin A, Swarbric J, Cammarata A. Micromeritics. In: Physical pharmacy. 3rd Ed. Bombay, K. M. Varghese Company; 1991:515-519.
Ford JL, Rubinstein MH, McCaul F, Hogan JE, Edgar PJ. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropyl methylcellulose matrix tablets. Int J Pharm. 1987;40:223
Cole ET, Rees JE, Hersey JA. Relations between compaction data for some crystalline pharmaceutical materials. Pharm Acta Helv. 1975;50(1-2):28-32.
Williams RO, Reynolds TD, Cabelka TD, Sykora MA, Mahaguna V. Investigation of excipient type and level on drug release from controlled release tablets containing HPMC. Pharm Dev Techno. 2002;7:181
Danish FQ, Parrott EL. Flow rate of solid particulate pharmaceuticals. J Pharm Sci. 1971;60:548-554.
Sangekar SA, Sarli M, Seth PR. Effect of moisture on physical characteristics of tablets prepared from direct compression excipients. J Pharm Sci. 1972;61:939-944.
Buchi N. Nalluri, S. Vidyasagar and K. M. Maheswari. Effect of Excipients on Oxcarbazepine Release from Modified Release Matrix Tablets. J Applied Pharm Sci. 2012; 02 (08): 150-158.
Lerk CF, Bolhuis GK, Deboer AH. Pharmaceutical dosage forms-tablets. Pharm Weekblad. 1974;109:945-955.
York P. Solid state properties of powders in the formulation and processing of solid dosage forms. Int J Pharm. 1983;14:1-28.
Pranjali Gawali, Anand Gupta, Sayali Kachare, Sanjay Kshirsagar. Formulation and Evaluation of Matrix-based Sustained Release Tablets of Quetiapine fumarate and the Influence of Excipients on Drug Release. J Chem Pharm Res 2012; 4(6):3073-3081.
Martin A, Swarbric J, Cammarata A. Micromeritics. In: Physical pharmacy. 3rd Ed. Bombay, K. M. Varghese Company ; 1991:515-519.
Zografi G, Tam SS. Wettability of pharmaceutical solids: Estimates of solid surface polarity. J Pharm Sci. 1976;65(8):1145-1149.
Cal S, Iglesias G, Souto C, Concheiro A, Gdmez-Amoza JL, Martinez-Pacheco R. Effects of hydration on the properties of a roller-dried fl-lactose for direct compression. Int J Pharm. 1996;129:253-261.
Nande VS, Barabde UV, Morkhade DM, Patil AT, Joshi SB. Synthesis and characterization of PEGylated derivatives of rosin for sustained drug delivery. React Funct Polym. 2006;(66):1373-1383.
Varma MVS, Kaushal AM, Garg A, Garg S. Factors affecting mechanism and kinetics of drug release from matrix based oral controlled drug delivery systems. Am J Drug Deliv. 2004;2(1):43-57.
Jadhav A. S., Tarkase K.N. Formulation Aspects With an Comparative Influence of Different Parameters Over Matrix Tablet. Int J Current Pharm Rev Res.2012; 3(2):33-42.
Reddy. K, Srikantha Kumar.P, Ranjit, Ramakrishna. S, Kulkarni Suresh V., Krishna Vamsi, Raghuram N. Influence of co-excipients on release rate of stavudine controlled release matrix tablets. J Pharm Res.2011; 4 (3): 773-778
Agoram B, Woltosz WS, Bolger MB. Predecting the impact of physiological and biochemical processes on oral drug bioavailability. Adv Drug Deliv Rev. 2001; 50:41-67.
Colombo P, Santi P, Bettini R, Brazel CS, Peppas NA. Drug Release from Swelling-Controlled Systems. In: Wise DL, eds. Handbook of Pharmaceutical Controlled Release Technology. New York; Marcel Dekker Inc.; 2000:187.
Roy DS, Rohera BD. Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices. Eu J Pharm Sci. 2002;16:193
Velasco MV, Ford JL, Rowe P, Rajabi-Siahboomi AR. Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J Contr Release. 1999;57:75
Sutapa Biswas Majee, Indranil Mitra and Gopa Roy Biswas. Influence of Excipient Combination on Release Kinetics from Solid Dispersion Tablets of a Model BCS Class II Drug. Res J Pharm, Biological and Chem Sci.2014;5(3): 1209-1220.
Siepmanna J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001;48:139
Bashar M, Al-Tanni, Tashtoush M. Effect of microenvironment pH of swellable and erodible buffered matrices on the release characteristics of diclofenac sodium. AAPS Pharmscitech. 2003; 4(3) Artical 43.
Thoma K, Ziegler I. pH-independent release of fenoldopam from pellets with insoluble film coats. Eur J Pharm Biopharm. 1998;46:105-113.
Heng PWS, Wan LSC, Ling BL. Assessment of powder cohesiveness in spheronization studies. Int. J. Pharm. 1995;116:119-123
Reynolds TD. Polymer erosion and drug release characterization of HPMC matrices. J Pharm Sci. 1998;87(7):1115-1123.
Liu J, Zang F, McGinity JW. Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot melt extrusion. Eur J Pharm Biopharm. 2001;52:181-190.
Leuenberger H, Bonny JD, Kolb M. Percolation effects in matrix-type controlled drug release systems. Int J Pharm. 1995;115:217-224.
Davidson GWR, Peppas NA. Solute and penetrant diffusion in swellable polymers V. Relaxation controlled transport in P(HEMA-co-MMA) copolymers. J Contr Release. 1986; 3:243
Ashok Kumar P. and Damodar Kumar S. Effect of hydrophilic and hydrophobic polymers and fillers on controlled release matrix tablets of acyclovir. Der Pharmacia Sinica, 2013; 4(3): 143-150
Manjanna K. M.,Rajesh K. S. and Pramod Kumar T. M. Effect of polymer diluent ratio on physicochemical properties of matrix tablets of aceclofenac sodium for oral controlled drug delivery. J. Chem. Pharm. Res. 2014; 6(2):635-648.
Jivraj M, Martini LG, Thomson CM. An overview of the different excipients useful for the direct compression of tablets. PSTT. 2000; 3(2):58-63.
Guojie xu, Hisakazu Sunada. Influence of Formulation Change on Drug Release Kinetics from Hydroxy propyl methylcellulose Matrix Tablets. chem pharm bulletin. 1995:43(3):483-487.
Murakami H, Yoneyama T, Nakajima K, Kobayashi M. Correlation between loose density and compactibility of granules prepared by various granulation methods. Int J Pharm. 2001;216:159
A Goyal, P shukla, A K Srivastava. Factors influencing drug release characteristic from hydrophilic polymer matrix tablet. Asian j pharm clin res. 2009; 2(1):93-98.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
- The author must submit Copyright form After acceptance of the article.
How to Cite
