Pharmaceutical evaluation of effects of hydrophilicity and hydrophobicity of three commonly used diluents on tablet formulation-Part I: IR tablets

Authors

  • Deepak S. K. Bharat Institute Of Technology Hyderabad
  • Pramod Parshuramkar University Dept of Pharmaceutical Sci. RTM Nagpur University Nagpur
  • Anusha V University Dept of Pharmaceutical Sci. RTM Nagpur University Nagpur
  • Mrunali Potbhare University Dept of Pharmaceutical Sci. RTM Nagpur University Nagpur
  • Arun T. Patil University Dept of Pharmaceutical Sci. RTM Nagpur University Nagpur

DOI:

https://doi.org/10.7439/ijpc.v5i3.1920

Abstract

The study deals with the effects of hydrophilicity and hydrophobicity of three commonly used diluents on IR tablets of model soluble and insoluble drugs. Conventional tablets with diluents, used individually and in combinations, were prepared by direct compression, dry granulation and wet granulation. Effects of binder amount, disintegrant and its time of addition were evaluated. Tensile strength, friability, disintegration, contact angle, wettability and dissolution of tablets were assessed. Results reveal that hydrophilicity and hydrophobicity of drug and diluents markedly influence various tablet properties and should be thoroughly considered prior formulations.

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Published

2015-04-01

Issue

Vol. 5 No. 3 (2015): Mar

Section

Research Articles

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How to Cite

1.
Pharmaceutical evaluation of effects of hydrophilicity and hydrophobicity of three commonly used diluents on tablet formulation-Part I: IR tablets. Int J of Pharm Chem [Internet]. 2015 Apr. 1 [cited 2026 Jan. 6];5(3):82-9. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1920
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