Development of A water soluble inclusion complex hydroxypropyl-?-cyclodextrin with disulfiram

Authors

  • Viktoriya Tyukova Lomonosov Moscow State University of Fine Chemical Technologies
  • Olga Novikova D. Mendeleyev University of Chemical Technology of Russia
  • Alexey Panov Lomonosov Moscow State University of Fine Chemical Technologies
  • Stanislav Kedik Lomonosov Moscow State University of Fine Chemical Technologies

DOI:

https://doi.org/10.7439/ijpc.v5i8.1793

Abstract

Disulfiram (DSF) was successfully used to treat cataract one of the most common eye disease. Unfortunately the usage of the DSF in ophthalmology is limited due to its low solubility in water. The objective of this article is to propose a new way to product an inclusion complex of DSF with hydroxypropil-?-cyclodextrin (HP?CD) that allows enhancing drug's solubility in water. The inclusion complex was prepared by dissolving of dry samples of HP?CD and DSF in ethyl alcohol with the molar ratio 2:1. To confirm complex formation and establish the structure we used differential scanning calorimetry, nuclear magnetic resonance spectroscopy and X-ray powder diffraction. We compared typical thermograms of disulfiram, physical mixture of DSF with HP?CD, inclusion complex of HP?CD and DSF. Thermogram of complex showed no melting peak for DSF. Complex shows the presence of signals on diffractogram that characterize the amorphous state of inclusion complex. The obtained product can be classified as freely soluble in water. We validated the molar ratio of HP?CD and DSF in the inclusion complex and proposed structure of the inclusion complex based on NMR.

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Author Biographies

  • Viktoriya Tyukova, Lomonosov Moscow State University of Fine Chemical Technologies
    Postgraduate student, Biomedical and Pharmaceutical Technologies
  • Olga Novikova, D. Mendeleyev University of Chemical Technology of Russia
    Student, Faculty of Natural Science
  • Alexey Panov, Lomonosov Moscow State University of Fine Chemical Technologies
    PhD, Biomedical and Pharmaceutical Technologies
  • Stanislav Kedik, Lomonosov Moscow State University of Fine Chemical Technologies
    Professor, Lomonosov Moscow State University of Fine Chemical Technologies

References

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Published

2015-09-03

Issue

Section

Research Articles

How to Cite

1.
Development of A water soluble inclusion complex hydroxypropyl-?-cyclodextrin with disulfiram. Int J of Pharm Chem [Internet]. 2015 Sep. 3 [cited 2025 Jul. 22];5(8):288-92. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1793