Pharmacological and synthetic profile of benzothiazepine: A review

Abstract

The 1, 5-benzothiazepines are important nitrogen- and sulfur-containing seven-membered heterocyclic compounds in drug research since they possess diverse bioactivities. 1, 5-Benzothiazepines are the most well-known representatives of benzologs of 1,4-thiazepine and one of the three possible benzo-condensed derivatives, and 1,5-benzothiazepines. The 1, 5-benzothiazepine derivatives are of particular interest for lead discovery because they have been found active against different families of targets.Therefore, the 1,5-benzothiazepines are useful compounds in the drug research which has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. Benzothiazepine and its derivatives exhibit diverse biological activities such as coronary vasodilatory, tranquilizer, antidepressant, antihypertensive, calcium channel blocker. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing 1, 5-benzothiazepines moiety that could be better agents in terms of efficacy and safety.