Antimicrobial analysis and structural elucidation of chloroform leaf extract of Adenia cissanpeloides

Authors

  • Augustina Obianuju Aboh Department of Chemistry, Nwafor Orizu College of Education, Nsugbe, Anambra State, Nigeria.
  • Vincent Egbulefu Ajiwe Department of Industrial Chemistry, Nnamdi Azikiwe University Awka, Anambra State,
  • Patrick-Anthony Chudi Okoye Department of Industrial Chemistry, Nnamdi Azikiwe University Awka, Anambra State,

DOI:

https://doi.org/10.7439/ijpc.v5i3.1518

Keywords:

Blood urea nitrogen to serum albumin ratio, Pneumonia Severity Index, CURB-65, community-acquired pneumonia, mortality, severity

Abstract

The leaf of Adenia cissanpeloides known as Nkochi ngwu or Uturu among the Igbos was studied to elucidate the structure of the pharmaceutical active ingredient present in the chloroform extract of the leaf. Thin layer chromatography showed a spot with Rf value of 0.85. The extract was subjected to spectroscopic analysis using FTIR, UV-visible, H1 NMR, C13NMR, GCMS and the structure elucidated was 1, 2-Benzene dicarboxylic acid dioctyl ester. Antibacterial and Antifungal activities of the pure extract using 10 bacteria species gram positive and gram negative such as S.aureus, E.coli, Streptococcus species, Proteus vulgaris, Enterobacter earogenes, Bacillus species, S.albus and fungal cultures such as Aspergilles flavus, Aspergillus niger and candida albican showed that the chloroform extract had zones of inhibition ranging from 16 to 36mm.These antimicrobial results were compared with that of some standard antibiotics and it was discovered that the chloroform fraction was more potent than the standard antibiotics.

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Author Biographies

  • Augustina Obianuju Aboh, Department of Chemistry, Nwafor Orizu College of Education, Nsugbe, Anambra State, Nigeria.
    Department of Chemistry, Principal Lecturer
  • Vincent Egbulefu Ajiwe, Department of Industrial Chemistry, Nnamdi Azikiwe University Awka, Anambra State,
    Department of Industrial Chemistry, Professor
  • Patrick-Anthony Chudi Okoye, Department of Industrial Chemistry, Nnamdi Azikiwe University Awka, Anambra State,
    Department of Industrial Chemistry, Professor

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Steadman

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Published

2015-03-30

Issue

Vol. 5 No. 3 (2015): Mar

Section

Research Articles

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How to Cite

1.
Antimicrobial analysis and structural elucidation of chloroform leaf extract of Adenia cissanpeloides. Int J of Pharm Chem [Internet]. 2015 Mar. 30 [cited 2026 Jan. 6];5(3):71-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1518
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