Synthesis and Antimicrobial Activity of Some Novel Chalcone Derived Quinolines
DOI:
https://doi.org/10.7439/ijpc.v4i4.100Abstract
A series of diversely substituted chalcone derived quinoline (3a-g) were synthesized from 2-chloro -8-methyl-quinoline-3-carbaldehyde and substituted acetophenones (1a-g) using Claisen-Schmidt condensation. New compounds were characterized by FT-IR, 1H- NMR and Elemental analysis. Antibacterial and antifungal activities of those compounds were determined by disc diffusion method against A. niger, A. flavus , (fungal strains), E. coli and P. aeruginosa (Gram negative bacteria), S. aureus and S. pyogenes (Gram positive bacteria) using Nystatin (for fungi) and ciprofloxacin (for bacteria) as a standard drugs. The in vitro antifungal and antibacterial screening of the chalcone derived quinoline (3a-g) revealed that most of the compounds in the series showed potent activity.Downloads
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2014-12-30
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Synthesis and Antimicrobial Activity of Some Novel Chalcone Derived Quinolines. Int J of Pharm Chem [Internet]. 2014 Dec. 30 [cited 2025 Jul. 5];4(4):134-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1467