Synthesis and Biological Evaluation of Some New 1,3,4-Oxa,Thiadiazole and 1,2,4-Triazole Derivatives attached to Benzimidazole

Authors

  • Hanan A. Abdel-Fattah Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519
  • A. Sh. El-Etrawy Organic Chemistry Department, College of Pharmacy & Drug Manufacturing, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, P. O. Box: 77
  • Noha Rayd M. Gabr Organic Chemistry Department, College of Pharmacy & Drug Manufacturing, Misr University for Science and Technology, Al-Motamayez District, 6th of the October, P. O. Box: 77

DOI:

https://doi.org/10.7439/ijpc.v4i3.91

Abstract

Some of novel benzimidazole derivatives bearing different heterocyclic moieties such as 1,3,4-Oxadiazole ?1, 3,4 -Thiadiazole and 1,2,4- Triazole were prepared. The structure of the new compounds were elucidated by IR , 1 H, 13 CNMR,MS spectra and elemental analysis .Some of the new compounds were evaluated for invitro cytotoxic activity against breast carcinoma(MCF-7) and colon carcinoma (HCT-116) cell line.Some of the tested compounds exihibited moderate cytotoxic activity .The preliminary antimicrobial activity of all of the novel compounds were investigated against Gram-positive bacteria ( Staphylococcus aureus and Staphylococcus epidermidis ), Gram-negative bacteria ( Escherichia coli and Pseudomonas aerugnosa ) and fungi ( Candida albicans )and the majority of the tested compounds exihibited promising antimicrobial activity.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Synthesis and Biological Evaluation of Some New 1,3,4-Oxa,Thiadiazole and 1,2,4-Triazole Derivatives attached to Benzimidazole. Int J of Pharm Chem [Internet]. 2014 Sep. 30 [cited 2026 Jan. 6];4(3):112-8. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1333
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