Development of force degradation profile of atenolol and chlorthalidone in combine tablet dosage form by (RP-HPLC)

Authors

  • Manoj S. Charde Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • A. S. Welankiwar Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • R. D. Chakole Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra

DOI:

https://doi.org/10.7439/ijpc.v4i3.85

Abstract

A force degradation profile of Atenolol (ATN) and Chlorthalidone (CTN) in combine tablet dosage form on RP-HPLC was developed using Comosil RP-C18 (4.6 x 250mm, 5m) in an gradient mode with mobile phase comprising of Methanol: Water (pH 3 using OPA) The flow rate was 1 mL/ min and effluent was monitored at 226 nm. The stress conditions selected on the basis of literature review and drug profile. The analysis of the marketed formulation shows the % RSD of 0.37 and 0.99 for ATN and CTN which fully agrees with system suitability. All the system suitability parameters were fully obeyed during generation of force degradation profile.

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Author Biography

  • Manoj S. Charde, Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
    Assitant Professor

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Development of force degradation profile of atenolol and chlorthalidone in combine tablet dosage form by (RP-HPLC). Int J of Pharm Chem [Internet]. 2014 Sep. 30 [cited 2026 Jan. 6];4(3):92-8. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1330
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