Synthesis, antimicrobial and QSAR studies of some new thiadiazepine derivatives

Authors

  • Dhanya Sunil Department of Chemistry, Manipal Institute of Technology, Manipal University, 576 104,
  • Puneeth Shetty Manipal University
  • Rama Murugappan Manipal University

DOI:

https://doi.org/10.7439/ijpc.v4i3.84

Keywords:

inflammatory pseudotumor, labial mucosa, lip, plasma cell granuloma

Abstract

A new series of thiadiazepine derivatives 3 a-l were synthesized from base catalysed reaction between chalcones and triazoles. They were characterized by advanced spectral techniques like IR, 1HNMR and mass spectroscopy and their antimicrobial studies were carried out. 3i exhibited excellent activity against gram +ve bacteria. 3g displayed significant antifungal activity. The logarithm of zone of inhibition of microorganisms were used for studying the quantitative structure activity relationships (QSAR) of the newly synthesized thiadiazepines and were carried out using Easy QSAR 1.0 by simple linear regression analysis. PaDEL Descriptor 2.13 predicted Eccentric connectivity index (ECCEN) and Chi path to be the best correlated QSAR model for antibacterial and anti-fungal activity of thiadiazepines against Staphylococcus aureus and Aspergillus niger respectively. The development of the best QSAR model for antimicrobial activity for thiadiazepines was confirmed by the high correlation between the observed and the predicted Log ZOI values.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Synthesis, antimicrobial and QSAR studies of some new thiadiazepine derivatives. Int J of Pharm Chem [Internet]. 2014 Sep. 30 [cited 2026 Jan. 6];4(3):83-7. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1328
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