Synthesis and antibacterial screening of some 3-(3-arylacryloyl)anthracen-10(9H)-ones
DOI:
https://doi.org/10.7439/ijpc.v4i2.82Abstract
Some 3-(3-arylacryloyl)anthracen-10(9 H )-one derivatives have been synthesized in two steps. In first step, anthracen-10-one (1) underwent Friedal Craft acetylation with acetyl chloride using anhydrous dichloromethane as a solvent and anhydrous powdered aluminum chloride as catalyst. 3-acetylanthracen-10(9 H )-one (2) so formed was then dissolved in absolute ethanol and reacted with substituted benzaldehydes in a base catalyzed reaction to form the target compounds(3a-g) . Reactions were monitored by thin layer chromatography using different solvent systems. Synthesized compounds were characterized using FTIR, H1-NMR and mass spectroscopic techniques. The compounds were screened for their antibacterial activity against two gram positive and two gram negative bacterial strains taking ciprofloxacin as a standard drug. Some of the compounds showed significant antibacterial activity.
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2014-06-30
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How to Cite
1.
Synthesis and antibacterial screening of some 3-(3-arylacryloyl)anthracen-10(9H)-ones. Int J of Pharm Chem [Internet]. 2014 Jun. 30 [cited 2025 Jun. 5];4(2):79-82. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1327
