Synthesis and Biological Evaluation of Some Novel pyrido[2,3-b]pyrazine derivatives as Potent TNF?alpha? inhibitors
DOI:
https://doi.org/10.7439/ijpc.v4i2.77Abstract
Two series of 3-Methyl-pyrido[2,3-b]pyrazine-2-yl)substitutedphenylamines 3a-f and N-(3-methylpyrido[2,3-b]pyrazin-2-yl)substituted benzenesulfonamides 4a-f were synthesized and evaluated as novel TNF-? inhibitors. The latter compounds were tested for their ability to inhibit the production of TNF-? in vivo in rats. Compounds 4b, c and d exploited potent inhibitory activity with IC 50 = 0.025, 0.040 and 0.053 nM respectively.Downloads
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2014-06-17
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How to Cite
1.
Synthesis and Biological Evaluation of Some Novel pyrido[2,3-b]pyrazine derivatives as Potent TNF?alpha? inhibitors. Int J of Pharm Chem [Internet]. 2014 Jun. 17 [cited 2025 Jul. 5];4(2):74-8. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1326
