Synthetic Development of Antimicrobial Novel Quinoxaline Derivatives

Abstract

A new approach to synthesize novel quinoxaline derivatives by a convenient and efficient route. All derivatives were synthesized from readily available benzil, ortho phenylene diamine and chlorosulfonic acid using different amines in ethanol as solvent. The reaction involves three steps which occurs in quick succession within appropriate time period to deliver the product with reasonably high yields. All the synthesized derivatives were subjected for their spectral analysis by FT-IR, ¹H-NMR, HRMS and antimicrobial screening by disk diffusion method and determination MIC by tube dilution technique. It was found that quinoxaline derivatives of on suitable concentrations have pronounced effect as compared to antibiotic as a reference standard (Azithromycin) present in the market against both the gram positive and gram negative bacteria. The results obtained suggest potential new drugs for antimicrobial activity.