(E)-1-(2,3-dimethoxyphenyl)-N-(4-methylpyridin-2-yl)methanimineas a potent anticancer agent against colorectal cancer

Authors

  • Dhanya Sunil Department of Chemistry, Manipal Institute of Technology, Manipal University, 576 104,
  • Ranjitha Ranjitha Department of Chemistry, Manipal Institute of Technology, Manipal University
  • Balaji S Department of Biotechnology, Manipal Institute of Technology, Manipal University, 576 104,
  • KSR Pai Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, 576 104,

DOI:

https://doi.org/10.7439/ijpc.v4i1.61

Abstract

Colorectal cancer is the third common malignancy in man, with a significant morbidity and mortality rate.Three Schiff bases were synthesized by aminocondensation of 4-methyl-2-amino pyridine and three aromatic aldehydes and characterized by CHN analysis and advanced spectral techniques. Theywere screened for their cytotoxic properties using Sulphorhodamine-B (SRB) assay,and their antimigratory properties using wound healing assay against HCT116 (human colon cancer)cell lines.( E )-1-(2,3-dimethoxyphenyl)- N -(4-methylpyridin-2-yl)methanimine (DMPM) exhibited very low IC50 in SRB assay with goodantimigratory activity as witnessed by wound healing assay. The protein processing enzyme MetAP2 has been identified as a molecular target for endothelial cell proliferation and angiogenesis and hence plays a key role in cancer therapy. The docking studies of DMPM with the active site of MetAP2 suggest it to bea potent chemotherapeutic agent in the treatment of colorectal cancer.

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Published

2014-02-20

Issue

Vol. 4 No. 1 (2014): Jan- Mar

Section

Research Articles

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How to Cite

1.
(E)-1-(2,3-dimethoxyphenyl)-N-(4-methylpyridin-2-yl)methanimineas a potent anticancer agent against colorectal cancer. Int J of Pharm Chem [Internet]. 2014 Feb. 20 [cited 2026 Apr. 2];4(1):11-4. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1316
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