Cyclic Voltammetric Studies of Simvastatin at Glassy Carbon Electrode Modified with Poly(p-toluene sulfonic acid).

Authors

  • Deepa M. B.
  • Mamatha G. P Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
  • Y. Arthoba Naik Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
  • B. S. Sherigara Kuvempu University, Jnana Sahyadri,Shankaraghatta-577 451, Karnataka

DOI:

https://doi.org/10.7439/ijpc.v3i1.32

Abstract

Glassy carbon electrode (GCE) is modified with electropolymerised film of p-toluene sulfonic acid (p-TSA). This polymer (p-TSA) modified electrode is used to study the electrochemical behavior of simvastatin (SMV), a lipid lowering drug in aqueous alcohol medium by Cyclic Voltammetry. It was found that the oxidation peak current of simvastatin at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH, supporting electrolyte concentration, % of solvent and concentration of simvastatin were examined. The proposed method was sensitive and simple. It was successfully employed to determine simvastatin in pharmaceutical samples.

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Author Biographies

  • Deepa M. B.
    Department of PG Studies and Research in Pharmaceutical Chemistry,
  • Mamatha G. P, Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
    Department of PG Studies and Research in Pharmaceutical Chemistry
  • Y. Arthoba Naik, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
    Department of P.G. Studies and Research in Chemistry,
  • B. S. Sherigara, Kuvempu University, Jnana Sahyadri,Shankaraghatta-577 451, Karnataka
    Department of P.G. Studies and Research in Industrial Chemistry,

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Published

2013-03-01

Issue

Vol. 3 No. 1 (2013): Jan-Mar

Section

Research Articles

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How to Cite

1.
Cyclic Voltammetric Studies of Simvastatin at Glassy Carbon Electrode Modified with Poly(p-toluene sulfonic acid). Int J of Pharm Chem [Internet]. 2013 Mar. 1 [cited 2026 Jan. 7];3(1):09-16. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1302
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