Synthesis of 5-p-chlorophenyl-2-substituted-1,3,4-oxdiazole and evaluation of its biological activities

Authors

  • Rajesh Kumar G.F.P.G.College, Shahjahanpur (U.P.)-242001
  • Mohd. Aslam G.F.P.G.College, Shahjahanpur (U.P.)-242001
  • N. U. Siddiqui G.F.P.G.College, Shahjahanpur (U.P.)-242001

DOI:

https://doi.org/10.7439/ijpc.v3i1.31

Abstract

A variety of new compounds 2-(1-pyrodinyl)-5-p-chlorophenyl-1,3,4-oxdiazole (III), 2-(benz-2,5-methoxy)-amino-5-p-chlorophenyl-1,3,4-oxdiazole (IV) and 2-(benz-2,`5`methyl-1-H-pyrazol-4-yl)azo-5-p-chlorophenyl-1,3,4-oxdiazole (V) was synthesized by the action of ester (p-chloromethylbenzoate) with hydrazine hydrate. All proposed structures were supported by IR, 1 H-NMR, 13 C-NMR and elemental analysis. These newly synthesized compounds (III,IV,V) have been screened for their antibacterial activity on E. coli, P. aeruginosa, S. aureus and S. pyrogenes and antifungal activity on C. albicans, A. niger and A. clavatus .

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Published

2013-03-01

Issue

Vol. 3 No. 1 (2013): Jan-Mar

Section

Research Articles

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How to Cite

1.
Synthesis of 5-p-chlorophenyl-2-substituted-1,3,4-oxdiazole and evaluation of its biological activities. Int J of Pharm Chem [Internet]. 2013 Mar. 1 [cited 2026 Jan. 7];3(1):04-8. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1301
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