A ONE-POT SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL INVESTIGATIONS: SCHIFF BASES
DOI:
https://doi.org/10.7439/ijpc.v2i3.608Abstract
Two biologically active Schiff bases, C13H10BrON (4) , C13H9Br2O2N (5) , were synthesized by the reaction of 2-aminophenol (1) with 3-bromobenzaldehyde (2) or 3,5-dibromo-4-hydroxybenzaldehyde (3) in the presence of conc. H2SO4. The characterization of Schiff bases were carried out by using spectroscopic techniques including IR, 1H-NMR, FAB-MS along with elemental analyses. The Schiff bases were checked for biological screening and Schiff base (4) was found to be potent antioxidant agent while Schiff base (5) showed non-significant antioxidant activity. In enzyme inhibition, the lipoxygenase inhibition activity was found to be moderate for Schiff base (4) and significant for Schiff base (5) . The Schiff bases (4-5) also have excellent antibacterial activity for strains; Bacillus subtilis, Staphylococcus aureus , Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa , using gentamicin as standard drug.Downloads
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Published
2012-10-01
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How to Cite
1.
A ONE-POT SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL INVESTIGATIONS: SCHIFF BASES. Int J of Pharm Chem [Internet]. 2012 Oct. 1 [cited 2026 Feb. 16];2(3):73-7. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1289
