CYCLIC VOLTAMMETRIC STUDIES OF GEMFIBROZIL AT POLY (GABAPENTIN) FILM MODIFIED GLASSY CARBON ELECTRODE

Authors

  • Mamatha G. P Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
  • Deepa M. B. Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
  • Y. Arthoba Naik Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
  • B. S. Sherigara Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
  • S. Manjappa Davangere University, Davangere, Karnataka
  • Pradeep G. Davangere University, Davangere, Karnataka

DOI:

https://doi.org/10.7439/ijpc.v2i2.500

Abstract

A polymerized film of gabapentin was prepared on the surface of a glassy carbon electrode (GCE) in phosphate buffer solution by electropolymerisation method using cyclic voltammetric technique. The poly (gabapentin) film modified glassy carbon electrode was calibrated with standard potassium ferrocyanide solution in 1 M KCl as a supporting electrolyte. This modified electrode used to study the electrochemical behavior of gemfibrozil, a lipid lowering drug in aqueous alcohol medium by cyclic voltammetric technique. It was found that the oxidation peak current of gemfibrozil at the modified GCE was greatly improved compared with that at the bare GCE. The effects of scan rate, pH, supporting electrolyte concentration, % of solvent and concentration of gemfibrozil were examined. With high sensitivity and selectivity, micro molar detection limit, high reproducibility together with ease of preparation and regeneration of the electrode surface make the electrode very stable for the determination of gemfibrozil in pharmaceutical and clinical preparations.

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Author Biographies

  • Mamatha G. P, Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
    Department of PG Studies and Research in Pharmaceutical Chemistry
  • Deepa M. B., Kadur PG Center, Kuvempu University, Kadur– 577 548, Karnataka
    Department of PG Studies and Research in Pharmaceutical Chemistry
  • Y. Arthoba Naik, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
    Department of P.G. Studies and Research in Chemistry and Industrial Chemistry,
  • B. S. Sherigara, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka
    Department of P.G. Studies and Research in Chemistry and Industrial Chemistry,
  • S. Manjappa, Davangere University, Davangere, Karnataka
    Department of P.G. Studies and Research in Chemistry,
  • Pradeep G., Davangere University, Davangere, Karnataka
    Department of P.G. Studies and Research in Chemistry,

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Published

2012-07-08

Issue

Vol. 2 No. 2 (2012): Apr-Jun

Section

Research Articles

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How to Cite

1.
CYCLIC VOLTAMMETRIC STUDIES OF GEMFIBROZIL AT POLY (GABAPENTIN) FILM MODIFIED GLASSY CARBON ELECTRODE. Int J of Pharm Chem [Internet]. 2012 Jul. 8 [cited 2025 Jul. 4];2(2):36-4. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1284
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