SYNTHESIS OF VARIOUS DITHIOCARBAMATE ESTERS THROUGH REGIOSELECTIVE THIOLATION OF 2-AMINOTHIAZOLE

Authors

  • Harish Kumar Chopra Department of Chemistry, Sant Longowal Institute of Engineering & Technology (Deemed University), Longowal, Sangrur-148106
  • Surendra Kumar Nayak Department of Chemistry, Sant Longowal Institute of Engineering & Technology (Deemed University), Longowal, Sangrur-148106
  • Paramjit Singh Panesar Department of Food Technology, Sant Longowal Institute of Engineering & Technology (Deemed University), Longowal, Sangrur-148106,

DOI:

https://doi.org/10.7439/ijpc.v1i1.197

Abstract

Dithiocarbamates are of significant importance as pesticides, vulcanizing agents and pharmaceuticals. In search of efficient regioselective strategy, the various dithiocarbamate
esters were synthesized by regioselective thiolation at endo-cyclic nitrogen of 2- aminothiazole. The treatment of Boc-protected 2-aminothiazole with carbon disulphide and
alkyl halide in the presence of potassium hydroxide in DMF afforded Boc-dithiocarbamate esters (3a-h). The removal of protecting group with TFA provided corresponding dithiocarbamate esters (4a-h). The formation of regioselective product was confirmed by spectral and molecular mechanical MM2 force field and PM3 approximation MOPAC energy minimization data. The strategy provides an important methodology for regioselective thiolation.

Downloads

Downloads

Published

2011-11-02

Issue

Section

Research Articles

How to Cite

1.
SYNTHESIS OF VARIOUS DITHIOCARBAMATE ESTERS THROUGH REGIOSELECTIVE THIOLATION OF 2-AMINOTHIAZOLE. Int J of Pharm Chem [Internet]. 2011 Nov. 2 [cited 2025 Jul. 21];1(1):01-9. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/1272