PREDICTION OF STRUCTURES OF BIOACTIVE PEPTIDES BY USING HOMOLOGY APPROACH

Authors

  • Shrikant Sharma Singhania Universitry, Jhunjhunu
  • Raghvendar Singh College of Biotechnology Sardar Vallabh Bhai Patel University of Agriculture & Technology. Meerut (U.P.)
  • Shashank Rana School of Life Science Singhania University Jhunjhunu (RJ)

DOI:

https://doi.org/10.7439/ijbar.v2i12.220

Keywords:

Essential Hypertension, Serum Lipoprotein(a).

Abstract

In silico study for prediction of structures of bioactive peptides by using homology approach and different bioinformatics tools as Basic Local Alignment Search Tool (BLAST) Swiss Model workspace repository and template were applied. The homology model comprises four main steps find out the homology model against query protein identification of structural template(s) alignment of target sequence and template structure(s) model building and model quality evaluation. The feasible structures of antimicrobial antithrombotic casein derived immunomodulatory and mineral binding peptides were designed. Antimicrobial peptide seq8 (NP_446175.1) was analyzed by using above stated methodology and found that 3E6U chain D showed homology with this sequence. Like this methodology was followed for all query bioactive peptide sequences.

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Author Biography

  • Raghvendar Singh, College of Biotechnology Sardar Vallabh Bhai Patel University of Agriculture & Technology. Meerut (U.P.)
    Bioinformatics Facility Department of Immunology

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Published

2012-01-01

Issue

Section

Original Research Articles

How to Cite

PREDICTION OF STRUCTURES OF BIOACTIVE PEPTIDES BY USING HOMOLOGY APPROACH. (2012). International Journal of Biomedical and Advance Research, 2(12), 478-488. https://doi.org/10.7439/ijbar.v2i12.220