LIPID PEROXIDATION MEASURED AS SERUM MALONDIALDEHYDE AND VITAMIN-C AS OXIDATIVE-ANTIOXIDATIVE BIOMARKERS IN TYPE II DIABETIC PATIENTS

Authors

  • Suchitra M. M. Department of Biochemistry, S V Institute of Medical Sciences, Tirupati,
  • Pallavi M. Department of Biochemistry, S V Iinstitute of Medical Sciences, Tirupati
  • Alok Sachan Department of Endocrinology, S V Institute of Medical Sciences, Tirupati
  • Seshadri V. Reddy Department of Biochemistry, S V Institute of Medical Sciences, Tirupati
  • Aparna R Bitla Department of Biochemistry, S V Institute of Medical Sciences, Tirupati
  • Srinivasa P.V.L.N. Rao Department of Biochemistry, S V Institute of Medical Sciences, Tirupati

DOI:

https://doi.org/10.7439/ijbar.v2i9.50

Abstract

Background: Oxidative stress (OS) has been implicated in the initiation, progression and pathology of type 2 diabetes mellitus (DM) and its associated complications.
Methods: Serum samples were screened for lipid peroxidation marker, malondialdehyde (MDA), Vitamin C (Vit-C), and lipid parameters from 35 type 2 diabetic patients without complications and 30 non-diabetic healthy controls.
Results: There were significant differences in all biochemical parameters in diabetic group compared to control group with a significant elevation in all the parameters but Vit-C and
high density lipoproteins (HDL) found to be decreased significantly (p 0.05). Pearson correlation analysis revealed that MDA was found to be negatively correlated with Vit-C (r =
0.28, p 0.05). Conclusion: Type 2 DM is associated with lipid abnormalities and OS causing increased lipid peroxidation and depleted antioxidant levels. As these changes might lead to diabetic complications, our findings suggest the supplementation of antioxidants as a therapeutic measure to type 2 DM patients.

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Published

2011-10-01

Issue

Vol. 2 No. 9 (2011): Sep

Section

Original Research Articles

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How to Cite

LIPID PEROXIDATION MEASURED AS SERUM MALONDIALDEHYDE AND VITAMIN-C AS OXIDATIVE-ANTIOXIDATIVE BIOMARKERS IN TYPE II DIABETIC PATIENTS. (2011). International Journal of Biomedical and Advance Research, 2(9), 378-388. https://doi.org/10.7439/ijbar.v2i9.50
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