ESTIMATION OF RECTAL TEMPERATURE AND BODY WEIGHT OF RAT AGAINST TYPHOID

Abstract

Typhoid fever (TF) is an important communicable disease in many developing countries. Salmonella, a gram negative bacilli, and can survive during certain stages of host parasite interaction. Nitric oxide (NO) is a versatile molecule produced in a biological system;previous studies have suggested that exogenous administration of L -arginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. Taking these facts in to consideration, it was thought pertinent to see the effect of oral administration of NO donors i.e. L-arginine. In this study have evaluated rectal temperature and body weight in Wistar rat before and after treatment of NO donor i.e., L-arginine and low doses of ciprofloxacin.