SYNTHESIS, ANTI-INFLAMMATORY AND ANTI-MICROBIAL ACTIVITY OF PYRIMIDINE-5-CARBOXYLATE DERIVATIVES

Authors

  • A. S. Dongarwar Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
  • B. E. Wanjari Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
  • M. V. Nema Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
  • P. P. Katolkar Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
  • A. O. Turaskar Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614
  • T. P. Nimbekar Manoharbahi Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614

DOI:

https://doi.org/10.7439/ijbar.v2i6.33

Abstract

Ethyl-2-amino-4-chloro-6-(2, 4, 6 trichloro phenyl amino) pyrimidine-5-carboxylate and ethyl-2-amino 4-chloro-1, 3-dimethyl-6-(phenyl amino)-1,2,3,4 tetrahydro pyrimidine-5-
carboxylate derivatives were synthesized through Cyclocondensation and Michel type of addition reaction with the aromatic anilines, guanidine and benzamidines. Synthesized novel
derivatives were confirmed by elemental analysis viz., IR, 1HNMR and Mass spectroscopy. These novel derivatives have been screened for Antibacterial, Antifungal and Antiinflammatory
activity.

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Published

2011-07-01

Issue

Vol. 2 No. 6 (2011): Jun

Section

Original Research Articles

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How to Cite

SYNTHESIS, ANTI-INFLAMMATORY AND ANTI-MICROBIAL ACTIVITY OF PYRIMIDINE-5-CARBOXYLATE DERIVATIVES. (2011). International Journal of Biomedical and Advance Research, 2(6), 188-197. https://doi.org/10.7439/ijbar.v2i6.33
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