Formulation and evaluation of immediate release tablets of Imipramine hydrochloride

Authors

  • Santosh Balaso Jadhav Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra
  • Audumber Digambar Mali Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra
  • Swapnil H. Rajeghadage Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra
  • Ritesh S. Bathe Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra

DOI:

https://doi.org/10.7439/ijbar.v5i11.980

Keywords:

Anxiety, HAMA scale, Yoga

Abstract

The aim of the present study is to develop and evaluate the immediate release tablet of Imipramine hydrochloride by direct compression method. The Superdisintegrantcrospovidone (CP), croscarmellose sodium (CCS) and sodium starch glycolate (SSG) were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibits highest dissolution using crospovidone showed faster drug release 99.65 % over the period of 12 min while disintegration time of the tablet was showed 28 sec comparison to other formulations of Imipramine hydrochloride.

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Author Biography

  • Santosh Balaso Jadhav, Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola, 413307, Solapur, Maharashtra
    pharmaceutics

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Published

2014-11-30

Issue

Vol. 5 No. 11 (2014): Nov

Section

Original Research Articles

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How to Cite

Formulation and evaluation of immediate release tablets of Imipramine hydrochloride. (2014). International Journal of Biomedical and Advance Research, 5(11), 559-565. https://doi.org/10.7439/ijbar.v5i11.980
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