Microbial Profile of Neonatal septicaemia in a tertiary care hospital of Bhopal

Abstract

Aims :To determine the microbial profile of neonatal septicaemia cases and antibiotic sensitivity pattern of aerobic isolates at a tertiary care hospital of Bhopal. Material and methods : In this retrospective study the laboratory data of blood culture reports of 256 neonates admitted to NICU,Peoples Hospital,Bhopal with clinical suspicion of septicaemia from July 2012 to December 2013 was analyzed. Results : Total 256 samples were received during the study period of which 174 (68%) were found to be positive of which 118(67.8%), 50(28.7%) and 5(2.87%) had Gram positive, Gram negative and Candidal infection respectively. Staphylococcus aureus and Klebsiella pneumoniae were the commonest isolates. Gram positive organisms were found to be most sensitive to Linezolid, Pristinomycin, Cefoxitin and Vancomycin. Imipenem, Levofloxacin and 3^rd generation Cephalosporins were found to be most effective against Enterobacteriaceae group. Pseudomonas and Acinetobacter sp. were found to be most susceptible to Imipenem, Aztreonam and Piperacillin tazobactam. Conclusion : This study emphasizes the need for longitudinal surveillance to be carried at regular intervals to describe the varied pathogens causing neonatal sepsis as well as their changing antibiotic susceptibility pattern which will provide a useful information base to guide practise and policies on rational use of antibiotics.