Serum cholinesterase as diagnostic marker of liver disease

Authors

  • Ruchi Shantilal Gokani S.B.K.S.M.I. & R.C., PIPARIA
  • Pranay Jadav Assistant Professor, Department of Community Medicine, GMERS Medical College, Gandhinagar, Gujarat
  • Nadeem Shaikh Resident, Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat
  • Rita Shah Professor & Head, Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat
  • Mitul Chhatriwala Resident, Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat
  • Bhavita Patel Ph.D. student, Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat

DOI:

https://doi.org/10.7439/ijbar.v5i9.890

Keywords:

Garlic, protein content, Channa punctatus

Abstract

Background: Liver disease is leading cause of morbidity and mortality worldwide. Cholinesteraseis a family of enzymes thatcatalysethehydrolysisof the neurotransmitteracetylcholineintocholineandacetic acid. It is an enzyme synthesized by hepatocytes and its serum levels reflect the synthetic function of liver. Objectives: To estimate serum cholinesterase in liver disease patients and to compare serum cholinesterase level with other liver function tests like SGOT, SGPT, ALP and Bilirubin levels. Methodology: The present cross sectional study was conducted at the Biochemistry department of tertiary care institute.Thirty patients with liver disease were included in the group A and 30 healthy patients not having liver disease were enrolled in group B as control .Serum cholinesterase and Liver Function Tests were estimated in all participants. Results: The level of cholinesterase were significantly lower in liver disease patients.Serum cholinesterase was 3424.77 2149.30 in group A vs.7320.77 1577.26 in group B (P 0.05). It is 90% sensitive and 100% specific. Conclusion: From the present study it is concluded that serum cholinesterase can serve as better diagnostic marker of liver disease.

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Published

2014-09-30

Issue

Vol. 5 No. 9 (2014): Sep

Section

Original Research Articles

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How to Cite

Serum cholinesterase as diagnostic marker of liver disease. (2014). International Journal of Biomedical and Advance Research, 5(9), 439-442. https://doi.org/10.7439/ijbar.v5i9.890
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