Evaluation of biochemical markers of renal dysfunction in prostate disorders and healthy controls

Abstract

Aims and Objectives: Prostate disorders like prostatitis, Benign prostatic hyperplasia (BPH) and prostatitis are the most common disorders of the male population, the latter two being prevalent in the elderly men. PSA being the gold standard parameter to identify these diseases, is not of much importance in the differential diagnosis of prostate disorders. This study focusses on the blood levels of PSA, Urea, BUN, Creatinine BUN/creatinine ratio and eGFR in various disorders of prostate and healthy controls. Methodology: Serum sample obtained from 25 patients each, diagnosed to have prostatitis, BPH and carcinoma prostate were analysed for the parameters mentioned above and compared with 75 age matched controls. Results: The mean values for PSA as well as other markers of renal function included in the study, were statistically significant between cases and controls. Further, significant values in the mean values of all the parameters were also observed in each of the prostate disorders as compared to controls. Conclusion: On the basis of our findings, we conclude that patients with prostate disorders are likely to progress into renal dysfunction. Also, based on the results of BUN /creatinine ratio, BPH and cancer of prostate ,the most common types of prostatic disorders in old age, are more prone to develop renal dysfunction.