Study of serum magnesium in type 2 Diabetes Mellitus and its correlation with the modality of treatment- A south Indian study

Abstract

Introduction: Hypomagnesaemia has been reported to occur with increased frequency in patients with type 2 diabetes mellitus; it is frequently overlooked and undertreated. Materials and Methods: A total of 50 patients with type 2 Diabetes Mellitus were recruited from the institutes medicine department. Fifty age and sex matched apparently healthy individuals with normal plasma glucose and with no symptoms suggestive of Diabetes mellitus were taken as controls. Both cases and controls were subjected to estimation of biochemical parameters.
Objectives: The present study was conducted with an objective to evaluate the serum magnesium and fasting blood glucose in type 2 Diabetes mellitus cases and compare them with controls. The present study also attempts to evaluate the possible relationship between the modality of treatment and serum magnesium levels.
Results: There is significant difference between levels of serum magnesium levels among diabetics and controls. The mean serum magnesium levels in cases and controls are 1.67 mg/dl and 2.03 mg/dl respectively (p 0.001). The mean serum magnesium levels in the OHA group, insulin group and the insulin+ OHA group were 2.02 mg/dl,1.59mg/dl and 1.25 mg/dl respectively.
Conclusion: The serum magnesium levels were significantly lower in the insulin treated group compared to the OHA treated group. The serum magnesium levels were also significantly lower in insulin treated group compared to the OHA group.