Role and efficacy of vancomycin-ceftriaxone combination for the treatment of serious Gram positive bacterial infections at tertiary care centre
DOI:
https://doi.org/10.7439/ijbar.v10i8.5240Keywords:
CVA (ceftriaxone-vancomycin), GPC (Gram-positive cocci), Vancomycin, FDC (Fixed-dose-combination)Abstract
Introduction: Infections caused byGram positive bacteria is the most common worldwide infection and the pattern of antimicrobial susceptibility varies widely in different geographical regions depending on the antibiotic policies and uses (CLSI 2018)vancomycin in combination with ceftriaxone given to the patients who suffer from the Gram positive bacterial infection.
Material and Methods: This study was prospective and conducted at department of Microbiology,Baba Raghav Das Medical College, Gorakhpur in eastern Uttar Pradesh. A total 258 clinical specimenscollected aseptically, which were further cultured on Sheep blood agar, MacConkey agar and nutrient broth. Antibiotic sensitivity was tested using Kirby-Bauer disk diffusion method on Muller-Hinton agar as per standard CLSI guidelines (2018).
Results:There were 258 clinical specimens cultured, in which male/female ratio was 1.15:1. Among 258 specimens, 121 (46.89%) were identified to be culture positive in which 70 (58%) foundGram negative bacilli followed by 41 (34%) Gram positivecocci and 10 (8%) were candida spp. All GPC isolates weretested forsensitivity and efficacyin between vancomycin-ceftriaxone (CVA) combination, vancomycin co-resistance with other antibiotics. Out of 41 isolated GPCs, 25 (60.97%) were confirmed asStaphylococcus aureus, 6(14.63%) reported as CoNS, 08(19.51%) streptococcus spp.and 2(04.87%) belongs to Enteroccusspp. CVA was found 100% sensitive in compared with vancomycin (80.5%).
Conclusion: Vancomycin resistance among Gram-positive isolates is an emerging health problem therefore the combination of ceftriaxone-vancomycin is recommended for the treatment of various infections (Bacteremia, septicaemia and meningitis etc.)when untreated causing severe life-threatening infections in human.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
How to Cite
