Drug Resistance by using the inhA promoter in clinical isolate for Mycobacterium Tuberculosis cases
DOI:
https://doi.org/10.7439/ijbar.v10i12.5205Keywords:
TB, katG gene, MTB, PCR, Isoniazid, CPAbstract
Tuberculosis is the most significant infectious disease it is caused by Mycobacterium tuberculosis (MTB). Bacteria that cause tuberculosis can develop resistance to antimicrobial medicines used to cure the disease. There is a multi-drug resistant tuberculosis TB that does not respond to at least Isoniazid and rifampicin, the two most powerful anti-TB drugs.Isoniazid Resistance Tuberculosis (IRTB) in M.tuberculosis is related to loss of catalase and peroxide (CP) activity in TB resistant strains. In other word, INH resistance often happens with the loss and/or decrease of CP or katG activity coded by katG gene. In fact, INH is a prodrug for which cellular activation is required by katG protein, before it
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