Correlation between clinical features and immunohistochemistry profile of lymphoma patients
DOI:
https://doi.org/10.7439/ijbar.v11i1.5086Keywords:
immunohistochemistry, Lymphomas, Immuno-Histochemistry (IHC), Hodgkin, Non-Hodgkin's LymphomaAbstract
Introduction: The Lymphomas are malignant neoplasm of the lymphoid cell lines commonly involving lymph nodes and account for up to 3% of all malignancies. These are mainly classified as either Hodgkin's or Non-Hodgkin's Lymphoma (NHL). The DLBCL appears to be the most common type of primary B- NH.Immuno-Histochemistry (IHC) is an integral part of diagnostic Hematopathology. Some IHC markers have impact on clinical features/presentation of Lymphoma. Stein et al observed CD30+ Anaplastic Large cell Lymphoma and its clinical features and found that Anaplastic Lymphoma Kinase positive (ALK)+Anaplastic Large Cell Lymphoma (ALCL) predominantly affects young male patients and, if treated with chemotherapy, has a favourable prognosis. Whereas ALK- ALCL occurs in older patients, affecting both genders equally and having an unfavourable prognosis.
Aims and Objectives: To study the correlations between Immuno-Histochemistry and clinical profile of lymphoma patients. Material and Methods: The present cross sectional study was carried out in 32 Biopsy and IHC proven newly diagnosed patients of lymphoma in the Dept. of Clinical Hematology of Pt. B.D. Sharma PGIMS, Rohtak from October2014-February2016.
Results : Mean age of the study population was 49.29
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