Haemostatic alterations in liver diseases

Authors

  • Sheetal Digambar Waghmare Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.
  • Narayan Ingole Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.
  • Nitin Gangane Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.

DOI:

https://doi.org/10.7439/ijbar.v5i5.748

Keywords:

Chronic obstructive pulmonary disease, Total Leucocyte Count, Differential Leucocyte Count

Abstract

Background - The liver is the major site of synthesis for all the clotting factors. The concentrations of these factors, especially factor V has been demonstrated to fall proportionately to the increasing severity of the disease. Liver disease also leads to vitamin K deficiency, mainly by the decreased absorption from the gut due to the reduced bile salts secretion from the liver. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of clotting and fibrinolytic systems and because the liver regulates the activation or inhibition of both systems. Objectives - The present study is designed to assess the values of various haemostatic parameters in liver disease. Results and Conclusions - On comparing the mean prothrombin time, activated partial thromboplastin time (APTT), thrombin time, and mean fibrinogen level in cases of liver disease with that in the controls, it was found to be significantly (p 0.001) increased in liver disease.

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Author Biographies

  • Sheetal Digambar Waghmare, Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.
    Assistant Professor Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram,
  • Narayan Ingole, Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.
    Professor
  • Nitin Gangane, Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram, Wardha, Maharashtra, India, Pin code - 442102.
    Professor and Head of Department (Pathology)Department of Pathology, Mahatma Gandhi Institute Of Medical Sciences Sewagram,

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Published

2014-05-30

Issue

Vol. 5 No. 5 (2014): May

Section

Original Research Articles

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How to Cite

Haemostatic alterations in liver diseases. (2014). International Journal of Biomedical and Advance Research, 5(5), 230-233. https://doi.org/10.7439/ijbar.v5i5.748
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