Comprehensive Analysis of Lipid Profile in Diabetic patients in Jamnagar, Gujarat

Authors

  • Nileshwari Himatlal Vala Associate Professor, Physiology Dept., Shri M.P. Shah Medical College, Jamnagar
  • Gitesh Jayprakash Dubal Tutor, Physiology dept, Shri M. P. Shah medical college, Jamnagar, Gujarat

DOI:

https://doi.org/10.7439/ijbar.v9i12.4947

Keywords:

Lipid Profile, Diabetes Mellitus

Abstract

Objectives: Nearly 415 million world population is affected by diabetes mellitus (DM). Changes in lipid profile has been investigated to be associated with DM. Present study thus has conducted comprehensive analysis of lipid profile in DM.

Methods: 50 cases each of Type 1 DM, Type 2 DM and control were included in present study which was conducted at Guru Gobindsinh Hospital, Jamnagar, Gujarat by Physiology department, M. P. Shah medical college. Apart from FBS and urine sugar, lipid profile (i.e. S. Cholesterol, S. Triglyceride, S. HDL, S. VLDL, S. LDL) was done using enzymatic colorimetric tests. Prior consent was taken from patients.

Results: 72% cases in S. cholesterol, 74% cases in S. triglyceride, 72% cases in S. VLDL, 78% cases in S. LDL were found to be higher in Type 2 DM but with 30% of cases having low S. HDL level, it was inconclusive for association with Type 2 DM. However, majority of cases of Type 1 DM had all lipid profile levels within normal range.

Conclusion: Results were comparable for both Type 1 and 2 DM with Mrunalini et al and Carolyn et al studies except for mean S. VLDL which was higher in present study compare to Carolyn et al study. To conclude Lipid profile was on higher side for Type 2 DM (except S. HDL which was inconclusive) but normal for Type 1 DM in majority of cases. In females

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References

Website: https://www.diabetes.co.uk/diabetes-prevalence.html

Website: http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

Mrunalini Kulkarni, Peter D. Reven Heart Protection Study, Current Diabetes Report; 2002; 69-73

Carolyn E. Walden M.S., Robert H. Knopp et al. Sex difference in the effect of diabetes mellitus on Lipoproteins, triglyceride & cholesterol concentration, The New England Journal of Medicine 1984; 311: 953-958.

Gylling H., Miettinen T.A., Cholesterol Absorption synthesis & LDL Metabolism in NIDDM; Diabetes Care; 1997; (1): 90-95.

Jerrold M. Olefsky, John W. Farquhar, Gerald M. Reaven, Reappraisal of the role of insulin hypertriglyceridemia, The American Journal of Medicine, 1974; 57: 551-560.

U. K. Prospective study 27. Plasma lipids & lipoprotein at diagnosis of NIDDM by age & sex. Diabetes Care; 1997; (11): 1683-7.

Valverkov AH, Chtup R. Ficker L. et al. Complementary insulin therapy improves blood glucose & serum lipid parameters in Type 2 DM. Exp. Clin. Endocrinal Diabetes 1997; 105 Sup. II 74-7.

Purnell J Q, Hokanson J.E., Marcovinas M. et al, Effect of excessive weight fain with intensive therapy of Type 1 Diabetes on Lipid levels & Blood Pressure. JAMA: 1998; 23: 280.

O'Neal D N, Lewicki J., Ansari M.Z. et al, Lipid levels and PVD in Diabetic and Non diabetic subjects: Atherosclerosis 1998; 136: 1-8.

Perez A., Wagner A.M., Carresas et al. Prevalence & phenotypic distribution of dyslipidemia in type 1 DM, effect of glycemic control, Archives of Internal Medicine 2000; 160: 2756-62.

T Salamanderis C, Panagiotopoulos S, Allen T. J. et al. Long term Intra individual variability of serum lipids in patients with Type 1 & 2 diabetes: Journal Diabetes complications 1998; 12: 208-14.

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Published

2018-12-08

Issue

Section

Original Research Articles

How to Cite

Comprehensive Analysis of Lipid Profile in Diabetic patients in Jamnagar, Gujarat. (2018). International Journal of Biomedical and Advance Research, 9(12), 388-391. https://doi.org/10.7439/ijbar.v9i12.4947