Major risk factors responsible for osteoporosis and osteoarthritis in general population of Karachi, Pakistan
DOI:
https://doi.org/10.7439/ijbar.v9i11.4941Keywords:
Academic Self-concept, Academic Self-concept, Intrinsic Motivation, Intrinsic Motivation, Extrinsic Motivation, Extrinsic Motivation, Academic Performance, Academic Performance, Self-esteem, Self-esteem, Psycho-educational Programmes, Psycho-educational ProgrammesAbstract
Background: Osteoporosis and osteoarthritis is the most common bone disorder, however, the cause of both OA and OP are unknown. It has thought that the inherent and environmental factors such as metabolic or endocrine issues, genetic variation, various types of injury and trauma are the most common causes to be involved in both the abnormalities.
Objectives: The purpose of this study is to determine the major risk factors responsible for osteoporosis and osteoarthritis in the general population of Karachi, Pakistan.
Method : A cross-sectional study was conducted among the general population of Karachi for the period of 13 months starting from March 2015 to April 2016. Total numbers of 123 respondents were selected and were divided into four groups based on age i.e. 18-25 years, 25-40 years, 40-50 years and over 50 years. The data that were collected including gender, alcohol intake, smoking status, dietary intake, post-menopausal stateandhormonal replacement. Analysis of data was carried out using SPSS Version 20.0.
Results: Out of 123 individuals participated in this study calcium intake among the respondents were highest in the age group of 18-25 years (95%). The rate of smoking was much higher in the age group 25-40 years (33.33%). Alcohol intake was found to be greater in the age group 40-50 years (20%). Arthritis was most common in the age group of 40-50 years (13.33%) whereas, the ratio of other diseases that can cause bone fragility was (48.38%) among the 50 above respondents.
Conclusion: The risk of developing osteoporosis and osteoarthritis is more among the individuals belonging to age group 50 years or above due to more frequent symptoms of low calcium in diet and presence of medical conditions related to the development of osteoporosis and osteoarthritis.
Downloads
References
Bartl R, Frisch B. Osteoporosis: diagnosis, prevention, therapy. Springer Science & Business Media. 2009.
Prentice A, Bonjour JP, Branca F, Cooper C, Flynn A, Garabedian M, Müller D, Pannemans D, Weber P. PASSCLAIM–Bone health and osteoporosis. European Journal of Nutrition. 2003; 42(1): i28-49.
Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, Van den Berg WB. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis and Cartilage. 2006; 14(1): 13-29.
Dequeker J, Aerssens J, Luyten FP. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clinical and Experimental Research. 2003; 15(5): 426-439.
Rutherford OM. The role of exercise in prevention of osteoporosis. Physiotherapy. 1990; 76(9): 522-526.
Stojanovic OI, Lazovic M, Lazovic M, Vuceljic M. Association between atherosclerosis and osteoporosis, the role of vitamin D. Archives of medical science: AMS. 2011; 7(2): 179-188.
Cooper C, Cook PL, Osmond C, Fisher L, Cawley MI. Osteoarthritis of the hip and osteoporosis of the proximal femur. Annals of the rheumatic diseases. 1991; 50(8): 540-542.
Brown, S. A., & Rosen, C. J. Osteoporosis. Medical Clinics of North America. 2003; 87(5): 1039–1063.
Sakalauskienė G, Jauniškienė D. Osteoarthritis: etiology, epidemiology, impact on the individual and society and the main principles of management. Medicina. 2010; 46(11):790.
Johnson, V. L., & Hunter, D. J. The epidemiology of osteoarthritis. Best practice & research Clinical rheumatology. 2014; 28(1): 5-15.
Consensus A. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993; 94(6): 646-50.
Cummings SR, Kelsey JL, Nevitt MC, O'DOWD KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiologic reviews. 1985; 7(1): 178-208.
Gordon MM, Hamilton J, Madhok R. Osteoarthritis of the knee. The Lancet. 1997; 350(9087): 1327-1328.
Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Committee to review dietary reference intakes for vitamin D and calcium, food and nutrition board, Institute of Medicine. DRI dietary reference intakes for calcium and vitamin D. 2011.
Kapoor D, Jones TH. Smoking and hormones in health and endocrine disorders. European Journal of Endocrinology. 2005; 152(4): 491-499.
Hogan HA, Sampson HW, Cashier E, Ledoux N. Alcohol consumption by young actively growing rats: a study of cortical bone histomorphometry and mechanical properties. Alcoholism: Clinical and Experimental Research. 1997; 21(5): 809-816.
Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone disease: Relationship to age and parathyroid hormone levels. Alcoholism: Clinical and Experimental Research. 1993; 17(3): 690-695.
Misra M. Long-term skeletal effects of eating disorders with onset in adolescence. Annals of the New York Academy of Sciences. 2008; 1135(1): 212-218.
Allain TJ, McGregor AM. Thyroid hormones and bone. Journal of Endocrinology. 1993; 139(1): 9-18.
Henry HL, Norman AW. Vitamin D: metabolism and biological actions. Annual Review of Nutrition. 1984; 4(1): 493-520.
Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American Journal of Clinical Nutrition. 2004; 80(6): 1678S-88S.
Kalyani RR, Corriere M, Ferrucci L. Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. The lancet Diabetes & endocrinology. 2014; 2(10): 819-829.
Stamm TA, Pieber K, Crevenna R, Dorner TE. Impairment in the activities of daily living in older adults with and without osteoporosis, osteoarthritis and chronic back pain: a secondary analysis of population-based health survey data. BMC musculoskeletal disorders. 2016; 17(1): 139.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 International Journal of Biomedical and Advance Research

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).