Comparative study of analgesic effect of intrathecal nalbuphine and tramadol in patients undergoing vaginal hysterectomy

Abstract

Aims: To compare the analgesic effect and block characteristics of intrathecal nalbuphine and tramadol in patients undergoing vaginal hysterectomy. Settings and design: Prospective, double-blind, randomized study on 80 patients of age 20-60 years, undergoing vaginal hysterectomy under spinal anaesthesia. Methods and Material: Random allocation in two groups, where group T and group N received 25 mg tramdol and 1 mg nalbuphine respectively along with 15 mg 0.5% hyperbaric bupivacine through intrathecal route. Drugs were administered at the L3-4 interspace with the patient in the sitting position. Spinal block was assessed by pin prick and modified bromage scale. In postoperative period time of first request of analgesia, number of rescue analgesia, the duration of motor block from the time of drug administration to the time when patient was able to lift his leg and the adverse effects were recorded. Quantitative variables were compared using Unpaired t-test/Mann-Whitney Test. Qualitative variables were correlated using Chi-Square test /Fisher exact test. A p value of 0.05 was considered statistically significant. Results: group N achieved faster onset of sensory block than group T (Group N=2.74