Synthesis And Biological Evaluation Of Benzimidazole Derivatives As An Antitubercular And Antimicrobial Agents

Abstract

Heterocyclic Compounds especially with Benzimidazole, Thiophene and Piperazine moieties were synthesized and investigated for their biological activities.
The Increasing global tuberculosis burden due to the curse of HIV, MDR and XRD TB has led to the search of newer therapeutic agents to tackle the menance.
The benzimidazole, Thiophene, Piperazine are an heterocyclic compounds. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with useful therapeutic activitiy such as antitubercular activity. literature shows that the benzimidazole, Thiophene, Piperazine derivatives are outstandingly effective compounds and a large number of reviews available for biochemical and pharmacological studies conformed that their molecules are useful against a wide variety of micro-organisms. Because of their importance, the methods for their synthesis have become a focus of synthetic organic chemists. Therefore in the present work study of chemistry of different derivative of substituted