Rocuronium vs Vecuronium: A comparison of Intubating condition, hemodynamic parameters and post-operative outcome in patients of coronary artery bypass graft surgery.
DOI:
https://doi.org/10.7439/ijbar.v4i12.555Abstract
Background: To compare Intubating condition, hemodynamic parameters and post operative outcome between Rocuronium as an Intubating agent followed by Atracurium as a maintenance and Vecuronium as Intubating and maintenance agent.Material and Methods: 50 patients posted for elective Off Pump CABG were divided into two groups. They were premedicated with Inj. Glycopyrrolate 5mcg/kg and Inj. Ondansetron 0.1 mg/kg. They were all preoxygenated with 100% O2 for 5 minutes. All patients were induced with Inj. Fentanyl 5mcg/kg and Inj. Midazolam 0.15 mg/kg IV. Group RA (n=25)patients were induced with Inj. Rocuronium 1mg/kg and in Group VV (n=25) were induced with Inj. Vecuronium 0.2mg/kg. They were all maintained with O2, Air, Isoflurane (0.2-0.6%), In RA group, anesthesia maintenance include infusion of Atracurium 0.5mg/kg/hr, Fentanyl 2mcg/kg/hr and Midazolam 5mcg/kg/hr. In VV group, Anesthesia was maintained by Intermittant bolus doses of Vecuronium 0.02 mg/kg, Fentanyl 2mcg/kg and Midazolam 0.02 mg/kg every hour.
Observation and Results: Patients were monitored for Intubating condition/ time of onset of muscle relaxant, hemodynamic parameters such as HR, MAP, SPO2, SVO2, PVR, PAP, SV, CO. Patients were observed for BIS and Neuromuscular monitoring (Train of Four). Intraoperative fluid and blood requirement, urine output and need of Inhalational agent requirement were compared.
Extubation time, complications, length of ICU stay and cost were compared,
Rocuronium has less time of onset with hemodynamic stability. In Group RA, hemodynamic stability was well maintained throughout the surgery, extubation time and complication rate were significantly lower than group VV.
Conclusion: Rocuronium was superior as Intubating agent. Combined use of Rocuronium followed by Atracurium provided more hemodynamic stability intraoperatively with better postoperative outcome.
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Published
2013-12-30
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How to Cite
Rocuronium vs Vecuronium: A comparison of Intubating condition, hemodynamic parameters and post-operative outcome in patients of coronary artery bypass graft surgery. (2013). International Journal of Biomedical and Advance Research, 4(12), 857-864. https://doi.org/10.7439/ijbar.v4i12.555
