Clinical Evaluation of Efficacy of Dexmedetomidine in Maintaining Intraoperative Haemodynamics in Posterior Fixation Surgery Following Traumatic Spine Injury
DOI:
https://doi.org/10.7439/ijbar.v8i4.4102Keywords:
Pyrimidine-5-Carboxylate, Aromatic anilines, Guanidines, Benzamidine, Antiinflammatory, Anti-microbial activityAbstract
Aim and Objectives: The present study was undertaken to compare the efficacy and safety of dexmedetomidine versus nitroglycerin in maintaining intraoperative haemodynamic stability and postoperative recovery profile in adult patients undergoing posterior fixation surgery for traumatic spine injuries. Methods: The study enrolling 60 patients of either sex (age 18-50 years), ASA grade I and II were randomly allocated into two groups of thirty patients each. Group DEX received dexmedetomidine 1?g/kg infusion (diluted in 50 ml of 0.9% normal saline) and group NTG received 50 ml of 0.9% normal saline infusion over a period of 10 min as bolus before premedication. The intraoperative haemodynamic parameters, estimated blood loss, operative time, intra and post operative complications, post operative sedation and recovery in patients were noted and compared between two groups. Results : Dexmedetomidine had better intraoperative haemodynamic stability than nitroglycerine, (p 0.05). The mean blood loss and duration of surgery was less with dexmedetomidine than with nitroglycerin, (p 0.01). Dexmedetomidine has fewer episodes of complications viz; tachycardia, bradycardia, hypotension and hypertension during and after surgery as compared to nitroglycerin. Post operative sedation was more with dexmedetomidine as compared to nitroglycerin, (p 0.05). Conclusion: Dexmedetomidine is an effective and safe agent in maintaining intraoperative hemodynamics in adults undergoing posterior fixation spine surgery.Downloads
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