ORAL CONTROLLED RELEASE METFORMIN HYDROCHLORIDE ION EXCHANGE RESINATE BEADS
DOI:
https://doi.org/10.7439/ijbar.v1i4.8Keywords:
Synchronous tumors, cervical cancer, ovarian carcinomaAbstract
Treating with ion exchange resin has chemically modified metformin hydrochloride to form an oral controlled release beads using ion-exchange resin sorption method. A strong cation exchange resin Amberlite IR 120 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug content and percentage drug release were determined spectrophotometrically at 233 nm. About 43% of drug was loaded in 4.5 h and in-vitro dissolution study showed 84% of drug release in 8 h. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Further, the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
How to Cite
