Study of Endometrial Pathology in Abnormal Uterine Bleeding
DOI:
https://doi.org/10.7439/ijbar.v8i2.3916Keywords:
Tuberculosis, nanopaRticles, Ligand, Lectin, AptamereAbstract
Objectives: To evaluate histopathology of endometrium in patients presenting with abnormal uterine bleeding and to find out the prevalence of various pathological conditions in endometrium in different age groups. Method: Total number of 300 cases clinically presenting with AUB were studied from October 2014 to September 2015. The study included endometrial curettage, biopsy and hysterectomy specimens. Results: Most common histopathological finding was proliferative phase and the most common abnormality detected was retained products of conception in 21- 40 years age group. Most common histopathological finding in 41- 50 years age group was also proliferative phase and the most common abnormality detected was endometrial hyperplasia. In 51- 60 years and >60years age groups, endometrial carcinoma constituted the most common pathology followed by endometrial hyperplasia. Conclusion: Histological examination of the submitted endometrial tissue remains the standard diagnostic procedure for the assessment of AUB. Establishing a cause of AUB is important, as medical therapy is effective in managing abnormal bleeding in most cases and should be attempted before surgical management. Histopathological evaluation of endometrium is especially indicated in women over the age of 35 years to rule out preneoplastic lesions and malignancies.Downloads
References
Kumar P, Malhotra N. Jeffcoate
Munro MG. Abnormal uterine bleeding in the reproductive years: Pathogenesis and clinical investigations. J Am Assoc Gynecol laparos.1999; 6:393-416.
Fraser IS, McCarron G, Markham R et al. Blood and total fluid content of menstrual discharge. Obstet Gynecol.1985; 65:194
Edward RG. Endometrial bleeding. Hum Reprod Update. 2007; 13(5):421-31.
Blaustein A. Pathology of the female genital tract. 2nd ed. New York: Springer-Verlag; 1994.p.279-31.
Rosai J. Rosai and Ackerman
Sutherland AM. Recent Advances in Obstetrics and Gynecology. Bourne A William JA.1962; 365-81.
Das A, Chugh S. Dysfunctional uterine bleeding- A clinicopathological study. Journal of Obstetrics and Gynaecology India.1964; 14(2):343-7.
Wagh KV, Swamy V. Functional uterine Haemorrhage. J Obstet and Gynecol India. 1964; 14: 87-392.
Mehrotra VG, Mukerjee K, Pandey M, Samanth V. Functional uterine bleeding (A review of 150 cases). J Obstet Gynaecol India. 1972; 22: 684-9.
Muzaffar M, Addeb K, Yasmeen S, Rehman M, Iqbal W, Khan M. Menstrual Irregularities with Excessive Blood Loss: a Clinico Pathological Correlation. Journal of Pakistan Medical Association. 2005; 55(11):486-9.
Saraswathi D, Thanka J, Shalinee R, Aarthi R, Jaya V, Kumar PV. Study of Endometrial Pathology in Abnormal Uterine Bleeding. Journal of Obstetrics and Gynecology India. 2011; 61(4): 426-30.
Bhosle A, Fonseca M. Evaluation and histopathological correlation of abnormal uterine bleeding in perimenopausal women. Bombay Hospital Journal. 2010; 52(1):69-72.
Takreem A, Danish N, Razaq S. Incidence of endometrial hyperplasia in 100 cases presenting with polymenorrhagia / menorrhagiain perimenopausal women. J Ayub Med Coll Abbottabad. 2009; 21(2):60-3.
Nayak SR, Vaidya R and Thakur S. Geriatric problem: Abnormal uterine bleeding per vaginum after the age of 40. Journal of Obetetrics and Gynaecology India.1976; 44(3): 580- 6.
Moghal N. Diagnostic value of endometrial curettage in abnormal uterine bleeding- a histopathological study. J Pak Med Assoc.1997; 47:295- 9.
Ara S, Roohi M. Abnormal uterine bleeding; histopathological diagnosis by conventional dilatation and curettage. Professional Medical Journal. 2011; 18(4):587-91.
Jairajpuri ZS, Rana S, Jetley S. Atypical uterine bleeding: histopathological audit of endometrium. A study of 638 cases. Al Ameen J Med Sci. 2013; 6(1):21-8.
Yusuf NW, Nadeem R, Yusuf AW. Dysfunctional uterine bleeding. A retrospective clinicopathological study over 2 years. Pak J Obstet Gynaecol. 1996; 9:27-30.
Wahda MT, Manal TA, Safwan I. Histopathological Interpretation of Abnormal Uterine Bleeding After the Age of 40 Year. The Iraqi Postgraduate Medical Journal. 2010; 9:274-82.
Bhatta S, Sinha AK. Histopathological study of endometrium in abnormal uterine bleeding. Journal of Pathology of Nepal. 2012; 2:297-300.
Parveen SH. Endometrium histology in abnormal uterine bleeding. Quarterly Medical Channel. 2011; 17(4):68-70.
Mahapatra M, Mishra P. Clinicopathological evalution of abnormal uterine bleeding. Journal of Health Research and Reveiws. 2015; 2(2):45-8.
Abdullah LS, Bondagji NS. Histopathological pattern of endometrial sampling performed for abnormal uterine bleeding. Bahrain Med Bull. 2011; 33(4):1-6.
Luqman M, Bukhari L. Abnormal/ Excessive uterine hemorrhage-
A histopathological study. Pakistan J Pathol.1998; 47:295-9.
Mahashewari V, ChakrabortyA, Tyagi S, Sharma R, Alam K, Moshin S. Endometrial changes in abnormal uterine bleeding. Journal of Obstetrics and Gynaecology India.1996; 33(4):389-94.
Dhangal G. A study of endometrium of patients with abnormal Uterine bleeding at Chitwan Valley. Kathmandu University Medical Journal. 2003; 1(2):110-2.
Damle RP, Dravid NV, Suryawanshi KH, Gardre AS, Bagale PS, Ahire N. Clinicopathological spectrum of endometrial changes in perimenopausal & menopausal uterine bleeding. Journal of clinical and Diagnostic Research. 2013; 7(12): 2774-6.
Khare A, Bansal R, Sharma S, Elhence P, Makkar N, Tyagi Y. Morphological spectrum of endometrium in patients presenting with dysfunctional uterine bleeding. People
Escoffery CT, Blake GO, Sargenat LA. Histopathological finding in women with postmenopausal bleeding in Jamaica. West Indian Med J. 2005; 51:232-5.
Baral R, Pudasini S. Histipathological pattern of endometrial samples in abnormal uterine bleeding. J Path Nepal. 2011; 1:13-6.
Asim SS, Akhter AZ. Frequency of malignancy in women presenting with postmenopausal bleeding. ANN Abbasi Shaheed Hosp Karachi Med Dent Coll. 2004; 9(1):506-9.
Gredmark T, Kvint S, Havel G, Mattsson LA. Histopathological Findings in Women with Postmenopausal Bleeding. Br J Obstet Gynaecol. 1995; 102(2):133-6.
Sarwar A, Haque A. Types and frequencies of pathologies in endometrial curettings of abnormal uterine bleeding. International Journal of Pathology. 2005; 3:65-70.
Khan S, Hameed S, Umber A. Histopathological pattern of endometrium on diagnostic D&C in patients with abnormal uterine bleeding. Annals. 2011; 17:166-70.
Mencalgia L. Hysteroscopy and adenocarcinoma. Obstet Gynecol Clin North Amer. 1995; 22:573-9.
Fraser IS. Blood and total fluid contents of menstrual discharged. Obstet Gynecol.1995; 65:194-8.
Pilli GS, Sethi B, Dhaded AV, Mathur PR. Dysfunctional uterine bleeding: Study of 100 cases. J Obstet Gynecol India. 2002; 52(3):87-9.
Vakiani M, Vavilis D, Agorastos T, Stamatopoulos P, Assimaki A, Bontis J. Histopathological findings of the endometrium in patients with dysfunctional uterine bleeding. Clin Exp Obstet Gynecol.1996; 23(4):236-9.
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