Anti Ulcer Activity of the Ethanolic and Aqueous Extracts Of Mikania scandens in Rats
DOI:
https://doi.org/10.7439/ijbar.v7i12.3720Keywords:
Diabetes, Dyslipidemia, Oxidative stress, Vitamin C, MalondialdehydeAbstract
Background: Mikania scandens (family: Asteraceae), known as climbing hempvine, is a twining herb with long petioles, opposite leaves and small monogamous flower heads. It has been used in traditional medicine as an analgesic and anti-inflammatory agent. Objective: The aim of the present study was to investigate the anti-ulcer activity of ethanol and aqueous extracts of aerial parts of the plant in Wistar albino rats. Materials and Methods: Ulcer was induced by pylorus ligation method in experimental Wistar albino rats. Gastric juice content, pH, free acidity, total acidity, ulcer index and percentage of ulcer protection were used for evaluation. The aerial parts of the plant were collected, shade dried, powdered and successively extracted with ethanol and water (1:10 w/v in g/mL).The extracts were separately collected using rotary evaporator. Percentage yield of ethanol and aqueous extracts were 17.6 g, (9.8% w/w) and 24.3 g, (15.5% w/w). The crude extracts were tested qualitatively for presence or absence of selected phytoconstituents. The anti-ulcer activity of ethanolic and aqueous extracts was carried for the two selected common doses (100 and 200 mg/kg of b.w per day orally) for each of the extract against the standard drug, [lansoprazole (pure drug suspension)] at a dose of (8 mg/kg) day orally. Results: The phytochemical study has revealed that both extracts of M. Scandens contain flavonoids, alkaloids, steroids, saponins and glycosides. The anti-ulcer activity, the two extracts was found significantly high (p 0.05) at the dose of 200 mg/kg orally compared to lansoprazole (8 mg/kg). Conclusion: The present study of aerial parts of M.scandens in ethanolic and aqueous extracts has shown to possess effective anti-ulcer activity.Downloads
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