Association of mineral levels with Chronic Kidney Disease (CKD-MBD) A hospital based retrospective study

Abstract

Background: There is a deep association between mineral and bone disorders in chronic kidney disease. High phosphate levels in CKD-MBD have been associated with increased all-cause mortality and cardiovascular morbidity and mortality. This study aims to find association of mineral levels with CKD-MBD. Objective is to get data of serum calcium and phosphorus levels in known CKD-MBD patients and evaluate their association with CKD-MBD. Methodology: This is a retrospective analytical study carried out at Dhiraj Hospital, Piparia, Vadodara. Total 71 consented indoor patients were enrolled in study out of 317 requested for consent in provided time period of 6 months, 45 (63.3%) patients with known CKD-MBD and 26 (36.6%) without CKD-MBD were taken as control group. Various laboratory parameters were evaluated and compared. Results: Out of 50 male and 21 female participants total 36 (80%) were found to have low calcium levels and 39 (86.67%) were found to have high phosphorus levels among known CKD-MBD patients which were classified according to eGFR. Conclusion: Low calcium and high phosphorus levels are associated in patients with CKD-MBD. There should be multi-disciplinary approach towards maintenance of mineral levels in patients to meet the K/DOQI guidelines.